High-intensity focused ultrasound ablation increases lymphocyte infiltration in mouse prostate tumor
نویسندگان
چکیده
Abstract Introduction and Objective: High-Intensity Focused Ultrasound (HIFU) is an FDA-approved procedure for the treatment of localized prostate cancer. HIFU destroys tumor tissue by noninvasively delivering ultrasonic energy, which rapidly heats targeted tissue. Prostate cancer has few tumor-infiltrating lymphocytes, are required antitumor immunity. The objective this study was to determine if activates immunity increases lymphocyte infiltration into tumor. Methods: RM1 tumors were grown on flanks syngeneic C57BL/6J mice one treated with HIFU. Contralateral growth monitored, collected at end assess immune cell infiltration. Tumor infiltrating lymphocytes flow cytometry. Results: When HIFU, contralateral (untreated) decreased when same type but not it a different type. increased CD4 +and CD8 +lymphocyte Depletion studies confirmed that effect dependent. Conclusions: In preclinical models, generates response capable suppressing mouse tumors. Future should investigate models metastatic cancer, where cytoreductive ablation can be combined systemic immunotherapies generate robust Homer Gloria Harvey Family Chair Fund in urologic oncology honor Stuart Friedman, M.D.
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.245.17